The chronobiological method

Skincare in Sync with Your Skin's Rythms

Our skin is governed by time.

Every cell follows innate 24-hour rhythms of protection and renewal. When these rhythms stay intact, the skin preserves its vitality, resilience, and youthful appearance. But when disrupted, cellular health declines and aging accelerates.

Discover GEZEITEN’s groundbreaking chrono-biological method - a new frontier in skin longevity. Through intelligent rituals, programmed ingredient release, and rhythm-correcting actives, we restore harmony at the cellular level, strengthening resilience and redefining how skin ages.

Why Your Skin’s Rhythm Matters

When your skin’s natural rhythm is disrupted, it can no longer function properly: during the day it loses efficiency in defending itself, and at night it struggles to repair. This leads to reduced DNA repair, weakened barrier function, increased dryness and sensitivity, and accelerated signs of aging.Balanced biorhythms are therefore essential for smooth, resilient, and youthful-looking skin.

Methodology

Methodology

[1] CHRONO-ADAPTIVE RITUALS
We design dedicated day and night rituals that sync with your skin’s natural rhythm, addressing its distinctive needs at every phase. Effortless in application, each product works in synergy to strengthen skin functionality and long-term health.

[2] PROGRAMMED INGREDIENT RELEASE
Our formulas feature intelligent release systems that deliver actives when the skin is most receptive. This maximizes efficacy while avoiding irritation.

[3] RHYTHM-CORRECTING THROUGH MARINE BIOTECHNOLOGY
Our ingredients actively help reset disrupted skin rhythms. They restore balance, strengthen resilience, and support long-term skin health.

6 – 9 AM Wake & Protect

10 AM – 2 PM Defense Mode & Cell Protection

3 – 6 PM Fatigue & Stress

7 – 10 PM repair process begins

11 PM – 4 AM Detox & Senescent Cell Clearance

2 – 4 AM Peak Repair & Renewal

4 – 5 AM Sensitivity & Reset

6 – 9 AM Wake & Protect

10 AM – 2 PM Defense Mode & Cell Protection

3 – 6 PM Fatigue & Stress

7 – 10 PM repair process begins

11 PM – 4 AM Detox & Senescent Cell Clearance

2 – 4 AM Peak Repair & Renewal

4 – 5 AM Sensitivity & Reset

6 – 9 AM Wake & Protect

10 AM – 2 PM Defense Mode & Cell Protection

3 – 6 PM Fatigue & Stress

7 – 10 PM repair process begins

11 PM – 4 AM Detox & Senescent Cell Clearance

2 – 4 AM Peak Repair & Renewal

4 – 5 AM Sensitivity & Reset

6 – 9 AM Wake & Protect

10 AM – 2 PM Defense Mode & Cell Protection

3 – 6 PM Fatigue & Stress

7 – 10 PM repair process begins

11 PM – 4 AM Detox & Senescent Cell Clearance

2 – 4 AM Peak Repair & Renewal

4 – 5 AM Sensitivity & Reset

6 – 9 AM Wake & Protect

10 AM – 2 PM Defense Mode & Cell Protection

3 – 6 PM Fatigue & Stress

7 – 10 PM repair process begins

11 PM – 4 AM Detox & Senescent Cell Clearance

2 – 4 AM Peak Repair & Renewal

4 – 5 AM Sensitivity & Reset

6 – 9 AM Wake & Protect

10 AM – 2 PM Defense Mode & Cell Protection

3 – 6 PM Fatigue & Stress

7 – 10 PM repair process begins

11 PM – 4 AM Detox & Senescent Cell Clearance

2 – 4 AM Peak Repair & Renewal

4 – 5 AM Sensitivity & Reset

6 – 9 AM Wake & Protect

10 AM – 2 PM Defense Mode & Cell Protection

3 – 6 PM Fatigue & Stress

7 – 10 PM repair process begins

11 PM – 4 AM Detox & Senescent Cell Clearance

2 – 4 AM Peak Repair & Renewal

4 – 5 AM Sensitivity & Reset

6 – 9 AM Wake & Protect

10 AM – 2 PM Defense Mode & Cell Protection

3 – 6 PM Fatigue & Stress

7 – 10 PM repair process begins

11 PM – 4 AM Detox & Senescent Cell Clearance

2 – 4 AM Peak Repair & Renewal

4 – 5 AM Sensitivity & Reset

6 – 9 AM Wake & Protect

10 AM – 2 PM Defense Mode & Cell Protection

3 – 6 PM Fatigue & Stress

7 – 10 PM repair process begins

11 PM – 4 AM Detox & Senescent Cell Clearance

2 – 4 AM Peak Repair & Renewal

4 – 5 AM Sensitivity & Reset

6 – 9 AM Wake & Protect

10 AM – 2 PM Defense Mode & Cell Protection

3 – 6 PM Fatigue & Stress

7 – 10 PM repair process begins

11 PM – 4 AM Detox & Senescent Cell Clearance

2 – 4 AM Peak Repair & Renewal

4 – 5 AM Sensitivity & Reset

CHRONOPHASE DAY ▪ THE SKIN'S DAYTIME RHYTHM


[6 – 9 AM] WAKE & PROTECT

The skin's barrier strengthens and sebum production begins, yet the skin looks tired due to nocturnal water loss.

FOCUS Strengthen the skin barrier, maintain hydration and prevent trans-epidermal water loss for a smoother, fresher complexion.


[10 AM – 2 PM] DEFENSE MODE & CELL PROTECTION

Sebum production peaks, the pH level is acidic and the antioxidant defence system is at its most active. The skin fights UV rays and pollution.

FOCUS Protect against blue light and digital aging, prevent photoaging and hyperpigmentation, defend against environmental stressors and free radicals – while supporting cellular vitality and resilience to preserve long-term skin longevity.


[3 – 6 PM] FATIGUE & STRESS

Hydration levels drop and oxidative stress rises. The skin looks tired, dull and stressed.

FOCUS Balance stress-induced skin ageing, slow collagen breakdown and loss of elasticity, and soothe inflammation to restore your glow, refine your pores, and improve your skin's uniformity.

DAY PRODUCTS

CHRONOPHASE NIGHT ▪ THE SKIN'S NIGHT-TIME RHYTHM


[7 – 10 PM] OPEN GATEWAY

Circulation increases, the skin becomes warmer and more permeable, and the repair process begins.

FOCUS Stabilising the microbiome, soothing the skin and preparing it to absorb actives.


[11 PM – 4 AM] DETOX & SENESCENT CELL CLEARANCE

The skin begins to eliminate senescent cells, which are dysfunctional cells that trigger inflammation and accelerate aging. This natural 'cellular disrepair management' process lies at the heart of longevity science, helping to maintain skin vitality over time.

FOCUS Activation of the skin’s innate longevity mechanisms by activating cellular renewal and recycling processes (autophagy), enhancing natural detox pathways, and preventing night-time water loss through intensive hydration. This ensures the skin recovers overnight and preserves its long-term health and resilience


[2 – 4 AM] PEAK REPAIR & RENEWAL

Cell repair and growth peak, and DNA is corrected and collagen built.

FOCUS Boosting collagen and elastin synthesis to restore firmness and elasticity and supply essential nutrients while the skin is most receptive.


[4 – 5 AM] SENSITIVITY & RESET

Skin is more sensitive, cortisol rises and the barrier rebuilds.

FOCUS Intensive replenishment, including hydration, calming, repair of inflammation-induced micro-damage and strengthening of the barrier.

NIGHT PRODUCTS

Prof. Dr. Gregor Eichele
Max-Planck-Institute

"GEZEITEN is a pioneer in the field of chronobiological skin care: their formulations go beyond established industry standards and are specifically tailored to the skin's internal rhythm. This scientifically based approach sets new standards."

- Director of the Department of Genes and Behaviour at the Max Planck Institute for Multidisciplinary Sciences, previously a faculty member at Harvard Medical School, Boston, USA

SCIENTIFIC TEAM

FOUNDER & HEAD OF INNOVATION

Michaela Hiltebrandt set out to redefine skincare by uniting nature and science with the body’s innate intelligence. Guided by the skin’s rhythms of protection and renewal, she develops formulas that combine purity, potency, and proven efficacy. Working closely with scientists and industry experts, she ensures...

LEADING CHRONOBIOLOGY SCIENTIST

Prof. Dr. Gregor Eichele, one of the world’s foremost chronobiology experts at the Max Planck Institute, has spent over 20 years studying the body’s internal clocks and their impact on regeneration. His pioneering research forms the scientific foundation of GEZEITEN, enabling formulas that work in...

MARINE BIOTECHNOLOGY

Under the direction of Prof. Dr. Pierre-Yves Morvan, CODIF Technologie Naturelle in Brittany, France, leads the field of marine biotechnology. With 40+ patented actives and over 200 clinical studies, CODIF combines advanced science with the resilience of the ocean - ensuring efficacy, traceability, and sustainability...

EPIGENETIC SCIENCE

Epigenetic research explores how lifestyle, stress, sleep, and environmental influences affect the way skin cells behave and regenerate. By translating these insights into formulations, GEZEITEN supports healthy gene expression and strengthens the skin’s long-term regenerative capacity - helping it stay balanced, youthful, and resilient over...

FORMULATION EXPERTISE

Every GEZEITEN formula is developed from the ground up by German chemists. Each blend contains more than 20 synergistic actives, precisely calibrated for maximum efficacy and tolerance. This approach eliminates unnecessary product layering and creates streamlined, intelligent routines that are dermatologically tested, microbiome-friendly, and uncompromising...

DERMATOLOGICAL & FACIALIST EXPERTISE

Dermatologists and leading aestheticians advise GEZEITEN throughout development, focusing on real concerns like sensitivity, pigmentation, and barrier weakness. Their practical insights ensure that every formula not only delivers clinical efficacy but also provides an elevated sensory experience, uniting professional expertise with visible results in daily...

Testimonials

HEATHER KEMESKY ∙ MODEL

How does that little bottle of liquid stardust turn my skin to glass?

NIKKI DEROEST ∙ MAKE-UP ARTIST

The most incredible packaging l've EVER laid eyes on.

LERA ABOVA ∙ ACTRESS & MODEL

The cream that did wonders to my 30 year young skin after 3 days.

LEANNE ELLIOTT YOUNG

Obsessed! It's just heaven! I've had so many DM's about it. Soo chic.

VERONIKA HEILBRUNNER

Obsessed.

Testimonials

HEATHER KEMESKY ∙ MODEL

How does that little bottle of liquid stardust turn my skin to glass?

NIKKI DEROEST ∙ MAKE-UP ARTIST

The most incredible packaging l've EVER laid eyes on.

LERA ABOVA ∙ ACTRESS & MODEL

The cream that did wonders to my 30 year young skin after 3 days.

LEANNE ELLIOTT YOUNG

Obsessed! It's just heaven! I've had so many DM's about it. Soo chic.

VERONIKA HEILBRUNNER

Obsessed.